魏海雷
发布者：管理员发布时间：2018-03-26作者：来源：点击量：
魏海雷 博士,研究员, 博士生导师
联系方式
农业部农业微生物资源收集与保藏重点实验室
中国农业科学院农业资源与农业区域研究所
地址：北京市海淀区中关村南大街12号中国农科院资源楼303
邮编：100081 电话：010-82106243
邮箱：weihailei@caas.cn
简介
魏海雷，男，1979年8月生于山东博兴。中国农业科学院农业资源与农业区域研究所，农业部农业微生物资源收集与保藏重点实验室，研究员，博士生导师。中国农业科学院知识创新工程海外引进人才。长期从事农业微生物的功能基因组学研究，主要研究方向包括：1）植物病原细菌III型分泌系统介导的效应蛋白组学及其与宿主植物的分子互作；2）土壤有益微生物资源的收集、功能与作用机制研究。先后主持参与国家863重大专项、国际科学基金、国家自然科学基金等项目，在Cell Host & Microbe，Cell Reports，EMBO Journal，Molecualr Plant Pathology，Molecular Microbiology，Cellular Microbiology，Frontiers in Plant Science等发表30多篇研究论文。目前兼任学术期刊Frontiers in Plant Science，Frontiers in Microbiology，Journal of Bacteriology Research副主编。
工作经历
2017.09- 研究员, 中国农业科学院农业资源与农业区划研究所
2013.01-2017.08 Reserch Associate, Dept. of Plant Pathology and Plant-Microbe Biology,
Cornell Unversity
2010.01-2012.12 Postdoc, Alan Collmer group, Dept. of Plant Pathology and Plant-Microbe Biology,Cornell Unversity
2006.12-2009.12 助理研究员, 中国科学院微生物研究所
2004.07-2006.11 研究实习员, 中国科学院微生物研究所
教育背景
2006.09-2009.06 植物与微生物学博士, 中国科学院昆明植物研究所
2001.09-2004.06 植物病理学硕士, 中国农业大学植物病理学系
1997.09-2001.06 植物保护学学士, 山东农业大学植物保护学院
研究领域
1.植物-微生物分子互作
2.有益微生物功能基因组学
主持科研项目
1.基于丁香假单胞效应蛋白多聚突变体D36E与Tn7-GATEWAY克隆技术的效应蛋白组学研究—国家自然科学基金 (31741106)
2.中国农业科学院创新工程引进人才启动项目(720-17)
3.云南烟草黑胫病发生及微生态控制研究--中国烟草总公司云南省公司科技计划重点项目(2017YN08)
4.生防假单胞杆菌Ⅲ型分泌系统组成基因的克隆与超微结构鉴定—国家自然科学基金(30700538)
Population diversity of culturable endophytic nicotine-degrading bacteria in tobacco (Nicotiana tabacum L.)--国际科学基金(F/4583-1)
“农作物重大病害多功能广谱生防菌剂研究和创制”子课题--”食线虫微生物的功能基因分子改造与菌剂制造”--国家“863”计划重大项目子课题(2006AA10A211)
学术兼职
1.副主编, Frontiers in Plant Science
2.副主编, Frontiers in Microbiology
3.副主编, Journal of Bacteriology Research
学术论文（按时间顺序）
1. Wei HL*, Zhang W, Collmer A*. Modular approach to the type III effector repertoire in Pseudomonas syringae pv. tomato DC3000 reveals a matrix of effector interplay in pathogenesis. Cell Reports, 2018, in press (*通讯作者)
2. Wei HL and Collmer A. Pseudomonas syringae pv. tomato DC3000 effector-depleted polymutants for studying functional interplay of type III effectors and minimal requirements for plant pathogenesis. Molecular Plant Pathology, 2017, doi : 10.1111/mpp.12655
3. Hatsugai N, Igarashi D, Mase K, Lu Y, Tsuda Y, Chakravarthy S, Wei HL, Foley JW, Collmer A, GlazebrookJ, Katagiri F. Plant effector-triggered immunity signaling sector is inhibited by pattern-triggered immunity. The EMBO Journal, 2017, 36, 2758-2769
4. Wang J, Wei HL*, Chang RK, Liu HQ, Wang YH. First report of Strawberry bacterial angular leaf spot caused by Xanthomonas fragariae in Tianjin, China. Plant Disease, 2017, 101(11): 1949 (*通讯作者)
5. Liu P, Zhang W, Zhang LQ, Liu XZ, Wei HL*. Supramolecular structure and functional analysis of the type III protein secretion system in Pseudomonas fluorescens 2P24. Frontiers in Plant Science, 2016, 6:1190. doi: 10.3389/fpls.2015.01190 (*通讯作者)
6. Lei L, Xia Z, Liu XZ, Wei HL*. Occurrence and variability of tobacco rhizosphere and phyllosphere bacterial ccommunities associated with nicotine biodegradation. Annals of Microbiology, 2016, 65: 163-173. (*通讯作者)
7. Wei HL, Chakravarthy S, Mathieu J, Helmann T, Stodghill P, Swingle B, Martin G, Collmer A. Pseudomonas syringae pv. tomato DC3000 type III secretion effector polymutants reveal an interplay between HopAD1 and AvrPtoB. Cell Host & Microbe, 2015, 17(6): 752-762.
8. Xia Z, Zhang W, Lei L, Liu X, Wei HL*. Genome-wide investigation of the genes involved in nicotine metabolism in Pseudomonas putida J5 by Tn5 transposon mutagenesis. Applied Microbiology and Biotechnology, 2015, 99(15): 6503-6514. (*通讯作者)
9. Lam HN, Chakravarthy S, Wei HL, BuiNguyen H, Stodghill PV, Collmer A, Swingle BM, Cartinhour SW. Global analysis of the HrpL regulon in the plant pathogen Pseudomonas syringae pv. tomato DC3000 reveals new regulon members with diverse functions. PLoS One, 2014, 9(8), e106115
10. Bao Z, Stodghill PV, Myers CR, Lam H, Wei HL, Chakravarthy S, Kvitko BH, Collmer A, Cartinhour SW, Schweitzer P, Swingle B. 2014. Genomic plasticity enables phenotypic variation of Pseudomonas syringae pv. tomato DC3000. PLoS One, 9(2), e86628
11. Wei HL, Chakravarthy S, Worley J, Collmer A. Consequences of flagellin export through the type III secretion system of Pseudomonas syringae reveal a major difference in the innate immune systems of mammals and the model plant Nicotiana benthamiana. Cellular Microbiology, 2013, 15: 601-618.
12. Wei HL and Collmer A. Multiple lessons from the multiple functions of a regulator of type III secretion system assembly in the plant pathogen Pseudomonas syringae. Molecular Microbiology, 2012, 85: 195-200.
13. Wu S, Lu D, Kabbage M, Wei HL, Swingle B, Records AR, Dickman M, He P, Shan L. Bacterial effector HopF2 suppresses arabidopsis innate immunity at the plasma membrane. Molecular Plant-Microbe Interactions, 2011, 24:585-593
14. Wei HL, Lei LP, Xia ZY, Liu PG, Liu XZ. PanB is involved in nicotine metabolism in Pseudomonas putida. International Biodeterioration and Biodegradation, 2009, 63: 988-992.
15. Lei LP, Zhang W, Wei HL, Xia ZY, Liu XZ. Characterization of a novel nicotine-degrading Ensifer sp. strain N7 isolated from tobacco rhizosphere. Annals of Microbiology, 2009, 59: 247-252.
16. Yan Q, Wu XG, Wei HL, Wang HM, Zhang LQ. Differential control of the PcoI/PcoR quorum-sensing system in Pseudomonas fluorescens 2P24 by sigma factor RpoS and the GacS/GacA two-component regulatory system. Microbiological research, 2009, 164:18-26.
17. Wei HL, Lei LP, Xia ZY, Liu S, Liu PG, Liu XZ. 2008. Characterization of a novel aerobic nicotine-biodegrading strain of Pseudomonas putida. Annals of Microbiology, 58:41-45.
18. Zhang W, Wei HL, Gao HW, Huang GH. Cloning and Characterization of ectABC Cluster from Bacillus alcalophilus DTY1. Chinese Journal of Biotechnology, 2008, 24:395-400.
19. Wei HL, Zhang LQ. Quorum sensing influence root colonization and biological control ability in Pseudomonas fluorescens 2P24. Antonie van Leeuwenhoek, 2006, 86:267-280.
20. Zhou HY, Wei HL, Liu XL, Wang Y, Zhang LQ, Tang WH. Improving biocontrol activity of Pseudomonas fluorescens through chromosomal integration of 2,4-diacetylphloroglucinol biosynthesis genes. Chinese Science Bulletin, 2005, 50:775-781.
21. 雷丽萍, 夏振远, 王玥, 魏海雷, 刘杏忠.尼古丁降解菌株L1的分离与降解特性. 农业生物技术学报. 2007, 4:721-722.
22. 魏海雷, 张力群.荧光假单胞杆菌2P24中gacS基因的克隆和功能分析. 微生物学报, 2005, 45(3):368-372.
23. 张薇, 魏海雷, 高洪文, 胡跃高.土壤微生物多样性及其环境影响因子研究进展. 生态学杂志, 2005, 24:48-52.
24. 张薇, 魏海雷, 张力群, 胡跃高.苜蓿菌核病生防菌及化学药剂的筛选. 草地学报, 2005, 13:162-165.
25. 张薇, 魏海雷, 张力群, 胡跃高, 储国良.紫花苜蓿菌核病原鉴定及其主要生物学特征. 草业学报, 2005, 14:69-75.
26. 魏海雷, 王烨, 张力群, 唐文华.生防菌株2P24与CPF-10的鉴定及其生防相关性状的初步分析. 植物病理学报, 2004, 34:80-85.
27. 魏海雷, 周洪友, 张力群, 王烨, 唐文华.抗生素2,4-二乙酰基间苯三酚作为荧光假单胞菌2P24菌株生防功能因子的实证分析. 微生物学报, 2004, 44:663-666.
会议摘要与墙报
1. Wei HL and Collmer A. “HrpH, a multipurpose lytic transglycosylase associated with the type III secretion system of Pseudomonas syringae pv. tomato DC3000” IS-MPMI XVII International Congress. (Portland, Oregon, July 2016)
2. Wei HL, Collmer A, Martin G. “Interplay between AvrPtoB and HopAD1 in Nicotiana benthamiana reveals a new kinase-interacting domain in HopAB family of effectors” 11th US-Japan Scientific Seminar. (Takamatsu, Japan, October 2015)
3. Wei HL, Martin G, Collmer A. “Pseudomonas syringae pv. tomato DC3000 effectorless polymutants reveal novel interplay between effectors” 2015 9th International Conference on Pseudomonas syringae and Related Pathogens. (Malaga, Spain, June 2015)
4. Wei HL, Chakravarthy S, Helmann T, Collmer A. “HopAD1 of Pseudomonas syringae pv. tomato DC3000 is a suppressor of flagellin-induced immunity and an elicitor of cell death in Nicotiana benthamiana.” 2013 10th International Congress of Plant Pathology. (Beijing, China, August 2013)
5. Chakravarthy S, Wei HL, Worley JN, Helmann T, Collmer A. “Functional structure of Pseudomonas syringae type III effector repertoires in the context of plant immunity” 2013 10th International Congress of Plant Pathology. (Beijing, China, August 2013)
6. Collmer A. Chakravarthy S, Wei HL. “Flagellin and the role of the Pseudomonas syringae type III secretion system in eliciting and suppressing immune responses independent of effectors.” IS-MPMI 2012 XV International Congress of Molecular Plant-Microbe Interactions. (Kyoto, Japan, August 2012)
7. Wei HL, Liu P, Zhang L, Liu X. “Supramolecular structure and genomic island of type III secretion system in plant growth-promoting Pseudomonas fluorescens 2P24.” 2009 American Phytopathological Society Annual Meeting. (Portland, Oregon, August, 2009)
8. 雷丽萍, 魏海雷, 夏振远, 杨开健, 刘硕, 刘杏忠. “panB基因在Pseudomonas putida代谢尼古丁中的功能.” 2009 第十一届中国科协年会. (中国重庆, 2009年9月)
9. 雷丽萍, 夏振远, 王玥, 魏海雷, 刘杏忠. “尼古丁降解菌L1的分离鉴定与降解特性分析.” 中国烟草学会第五届理事会第三次会议暨学术年会. (中国广州, 2007年3月8日)
10. 魏海雷, 张力群. “调控基因gacS在生防荧光假单胞杆菌2P24中的作用.” 中国植物病理学会2004年学术年会. (中国宁波, 2004年9月1日)
特邀报告
1.“Type III secretion system-associated effectoromics: development of a model Pseudomonas syrinage-Nicotiana benthamiana pathosystem” 河北省农林科学院植物保护研究所. (中国保定, 2016年12月26)
2.“Pseudomonas: A Model System in Biology--Three case studies of plant and soil inhabitants” 中国农业科学院农业资源与农业区划研究所. (中国北京, 2016年8月12日)
3.“Type III secretion system-associated effectoromics: recent advances in a Pseudomonas syrinage-plant pathosystem” The 4th International Symposium on Genomics and Crop Genetic Improvement & Nanhu Forum of Plant Science. (中国武汉, 2016年8月8日)
4.“Pseudomonas syringae pv. tomato DC3000 effectorless polymutants reveal novel interplay between effectors” The 9th International Conference on Pseudomonas syringae and Related Pathogens. (Malaga, Spain, June 2015)
5.“Plant pathogens and integrated innate immunity to infection-- Nicotiana benthamiana & Pseudomonas syringae pv. tomato DC3000 interaction as a model” 天津农学院园艺系. (中国天津, 2013年9月10日)
6.“HopAD1 of Pseudomonas syringae pv. tomato DC3000 is a suppressor of flagellin-induced immunity and an avirulence determinant in Nicotiana benthamiana” The 10th International Congress of Plant Pathology. (中国北京，2013年8月28日)
7.“The ins and outs of bacterial flagellin perception reveal a fundamental difference in the innate immune systems of plants and mammals” Mini-symposium: Microbial Friends & Foes: Cooperation and Conflict in Interspecific Associations. (Ithaca, NY, September 25, 2012)